The series is set 97 years after a devastating nuclear war wiped out almost all life on Earth. The only known survivors are the residents of twelve space stations in Earth's orbit prior to the war. The space stations banded together to form a single massive station named "The Ark", where about 2,400 people live. Resources are scarce and all crimes no matter their nature or severity are punishable by death ("floating") unless the perpetrator is under 18 years of age. After the Ark's life support systems are found to be critically failing, one hundred juvenile prisoners are declared "expendable" and sent to the surface in a last ditch attempt to determine if Earth is habitable again. The teens arrive on a beautiful planet they've only seen from space. Confronting the dangers of this rugged new world, they struggle to form a tentative community. However they discover that not all humanity was wiped out. There are people on Earth who survived the war, called "grounders" by the 100. The ...

The teenagers Marcus, Liz, Craig and Nina are camping in the remote outback of Australia. While driving on the road, a road train crashes on their car that leaves the road in a serious accident. The quartet survives and Craig breaks his arm, but their car is totally wrecked. However they see the train truck parked on road and Marcus and Liz walk to the vehicle to ask for help. They do not find the driver and soon Craig and Nina arrive. When they see the driver shooting at them, they decide to carjack the road train. Soon they begin to act strange possessed by some evil force.